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Thrombocytopenia Treatment Market - Opportunity Analysis, 2018-2026

Thrombocytopenia is a disorder in which a patient has low level of platelets in the blood. The major causes of thrombocytopenia are inefficient production of platelets, platelet splenic sequestration, and accelerative destruction of platelets. The most common ineffective production of thrombocytes are due bone marrow failure syndrome such as myelodysplastic syndrome and aplastic anemia. Thrombocytopenia can be inherited or acquired. In 2014, According to a research article published in Professional Med J, 2014, entitled Frequency of Thrombocytopenia, the frequency of thrombocytopenia is higher for people aged 60 years and above, suffering from non-cirrhotic liver disease. However, rampant discovery coupled with the ability to clone thrombopoietin has resulted in new treatment opportunities for clinical manifestation.

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More specific treatment plans usually depend on the underlying etiology of thrombocytopenia. In most cases the underlying cause of thrombocytopenia is not known, especially in the case of severe bleeding. In September 2015, Lusutrombopag, an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist developed by Shionogi Inc., received approval by Pharmaceuticals and Medical Devices Agency of Japan. Lusutrombopag helped enhance chronic liver disease (CLD) associated with thrombocytopenia for patients scheduled to undergo invasive procedures.

Lusustrombopag acts specifically on human thrombopoietin (TPO) receptors and stimulates signaling pathways that trigger the proliferation and differentiation of bone marrow cells into megakaryocytes. Thus, increasing the blood platelet count. However, patients treated with Lusustrombopag further showed higher counts of blood leukocytes and erythrocyte. Furthermore, in June 2017, FDA accepted application for new oral investigational drug, Tavalisse (fostamatinib disodium), by Rigel Pharmaceuticals, Inc. This drug is designed to inhibit the spleen tyrosine kinase and treat patients suffering from chronic or persistent immune thrombocytopenia. 

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Key Vendors:

3SBio Inc., Amarillo Biosciences, Inc., Amgen Inc., Baxalta Incorporated, Bayer AG, Boehringer Ingelheim GmbH, Bristol-Myers Squibb Company, Cellerant Therapeutics, Inc., Eisai Co., Ltd., Hansa Medical AB, Intas Pharmaceuticals Ltd., Merck & Co., Inc., Momenta Pharmaceuticals, Inc., Myelo Therapeutics GmbH, Neumedicines Inc., Novartis AG, Pfizer Inc., Prophylix Pharma AS, Rigel Pharmaceuticals, Inc., Shionogi & Co., Ltd., STATegics, Inc., and ViroMed Co., Ltd.

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Cervical Dysplasia Diagnostic Market Opportunity Analysis 2018-2026

Cervical dysplasia is a precancerous condition characterized by abnormal growth of endocervical canal cells. Cervical dysplasia is also called as cervical intraepithelial neoplasia. It is a Sexually Transmitted Disease (STD) caused due to human papillomavirus (HPV) infection. Cervical dysplasia can be of two types based on the type of cells it affect — squamous intraepithelial lesion and glandular cell lesions. It occurs in all age groups and it is common in women with 30 years age.

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Cervical dysplasia can be detected by Pap test, endocervical curettage, and loop electrosurgical excision procedure (LEEP) or HPV DNA test. The cervical dysplasia diagnostic market is expected to witness significant growth over the forecast period, owing to increasing prevalence of disease and increasing awareness regarding utilization of detection test through government screening programmes for regular screening for human papillomavirus.

Cervical infection is major risk factor for progression of HPV. Currently, conventional Pap smear test or HPV test are the only test available for screening cervical infection, which in turn propels the demand for development of DNA-based molecular testing to detect human papillomavirus for diagnosis of cervical cancer. For instance, in 2016, Becton, Dickinson and Company received pre-diagnostic market approval from FDA for its Onclarity HPV assay, type of HPV test.

However, current practices for cervical dysplasia diagnostic through colposcopy requires trained professional to perform the test, which is major challenge for growth of the market. To overcome this, research institutes and universities are involved in development of innovative diagnosis devices, which in driving growth of the cervical dysplasia diagnostic market. For instance, in July 2017, Duke University in North Carolina developed a pocket colposcopy device enable with laptop and mobile connection. The device was funded by National Institutes of Health (NIH).

On the basis of region, cervical dysplasia diagnostic market is segmented into North America, Europe, Asia Pacific, South America, and Middle East. Increasing awareness regarding cervical dysplasia screening programs and technological advancements in screening are the key factors fuelling growth of the North America cervical dysplasia diagnostic market. Moreover, market in Asia Pacific region is expected to witness significant growth over the forecast period, owing to increasing government funding for cervical research and improving healthcare infrastructure.

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Key Vendors:

Abbott Laboratories, Qiagen N.V., Hologic Inc., F. Hoffmann La-Roche Ltd., Quest Diagnostics Inc., Becton, Dickinson and Company, Atmos, and Karl Kaps.

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Low Molecular Weight Heparin Market Opportunity Analysis 2018-2026

Low Molecular Weight Heparins (LMWH) are a form of pharmacological anticoagulant intervention. Low molecular weight heparin is used for prophylaxis of deep vein thrombosis and pulmonary embolism, or thrombosis occurring in a broad spectrum of clinical indications, including general or orthopaedic surgery, neurosurgery, trauma, unstable angina, and myocardial infarction. LMWHs are derived from UFH by chemical or enzymatic depolymerisation to yield fragments that are around one third the size of heparin.

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However, it is associated with higher anticoagulant effect and provides higher bioavailability after subcutaneous administration, as compared to unfractionated heparin (UFH), for thromboembolic indications. Low molecular weight heparin is the most suitable anticoagulant in case of complicated pregnancy, as it eliminates risk of crossing the placental membrane. Low molecular weight heparin market growth attributed to advantages of low molecular weight heparin over unfractionated heparin. Unfractionated heparin or standard heparin varies in action from patient to patient. Thus, it can only be administered by hospitalized patients under monitoring, while low molecular weight heparin can be used subcutaneously once a day,  without the need for monitoring.

Increasing inclination of research institutes towards developing novel alternatives for available LMWH treatments is expected to widen the range of therapies, while narrowing down its side effects. For example, American University of Beirut Medical Centre sponsored the study for a drug, bemiparin sodium (a form of LMWH), which is in phase 4 and is expected to be completed in mid-2018, to improve the pregnancy outcomes in patients with recurrent implantation failure undergoing IVF/ ICSI treatment.Additionally, companies are collaborating with hospitals to strengthen their product portfolio. For instance, Bayer in collaboration with Assistance Publique - Hopitaux de Paris is studying combination of rivaroxaban and low molecular weight heparin for neoplasm and venous thromboembolism, which is in phase 3. Both these pipeline drugs are expected to complete their final stages of study during the forecast period, which in turn is expected to enhance the low molecular weight heparin market.

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Key Vendors:

Sanofi, Amphastar Pharmaceutical Inc., Teva Pharmaceuticals Industries Inc., Pfizer, Inc., LEO Pharmaceutical Products, Celgene Corporation, Sandoz GmbH (a division of Novartis AG), and Changzhou Qianhong Bio-pharma co. Ltd.

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Measles Mumps and Rubella (MMR) Vaccines Market Opportunity Analysis, 2018 – 2026

Measles, mumps, and rubella are the three common contagious airborne diseases that are highly caused by virus transmitted by sneezing and coughing of the infected person, which could lead to serious complications or death among children. Vaccines of these diseases are sold as attenuated viral vaccines, manufactured in a lyophilised formulation, which requires reconstitution with water for injection diluent and are available in two forms i.e. monovalent as well as combinational vaccines. Combinational MMR vaccines comprises mixture of two or more viral strains.

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These measles, mumps, and rubella vaccines are administered by subcutaneous injection to children as well as adults. It is generally administered to children aged 1 year and second dosage can be administered as early as one month after the first dose. According to CDC, two doses of measles, mumps and rubella vaccine are 97% effective against measles and 88% effective against mumps. One dose of measles, mumps, and rubella vaccine is 93% effective against measles, 78% effective against mumps, and 97% effective against rubella.

Currently, few vaccines available in the measles, mumps, and rubella vaccine market are sold under the trade name of M-M-R II, ProQuad, and Attenuvax by Merck Co. Inc.; Varilrix, Priorixtetra and MMR by GSK; Trimovax by Sanofi Pasteur and Tresivac by Serum Institute of India.

In spite of several governmental initiatives, measles is a leading cause of death among young children. Therefore, increasing success rate of vaccination programmes depends on government initiatives of each country. Some organizations are focusing on initiative, in order to reduce the prevalence of these diseases. For instance, GAVI Alliances has undertaken an initiative to provide vaccination in high-risk countries such as Afghanistan, Chad, Ethiopia, the Democratic Republic of the Congo, Nigeria and Pakistan. Similarly, in 2017, the Government of India launches Pan-India Measles-Rubella vaccination campaign, under which children ages from 9 months to 15 years are vaccinated to reduce the incidence of these disease in children. Such initiatives by various organizations and governments is expected to aid in growth of the market. Furthermore, development of combinational vaccines could aid in reducing cost and adverse effects by reducing the number of vaccination programme.

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Key Vendors:

GlaxoSmithKline (Belgium), Merck & Co. Inc. (USA) and Serum Institute of India Ltd, among others.

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PoC Platform & Technology Market to Surpass US$ 45.4 Billion by 2025

The point-of-care platforms and technologies have significantly contributed to the transformation of healthcare landscape by bringing rapid diagnosis and monitoring tests closer, and making it more convenient for healthcare providers and patients. The test results obtained by electronic health records (EHR) assists in quicker diagnosis leading to faster decision making and early treatment onset. The POC tests and devices help alleviate various pain points of hospital-based healthcare providers who are under constant pressure for delivering cost and time efficient care that enhances treatment outcomes of patients. These rapid POC tests address the issues of latency in test results by facilitating accurate evidence-based triage and diagnostic decisions within fraction of time when compared to the time taken by centralized laboratory tests.

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POC devices allow medical professionals to make decisions in patient’s vicinity, which results in significant healthcare delivery with faster results and immediate clinical management. The novel point-of-care tests (POCTs) offer diagnostic techniques for the prevention and treatment of infectious diseases such as HIV, Hepatitis B Virus, and chronic diseases such as diabetes, cancer, and cardiovascular disorders. According to the International Journal of Nanomedicine, in 2017, around 36.7 million people were affected by Human Immunodeficiency Virus (HIV) and around 400 million people were affected by viral hepatitis across the globe.

The survey also stated that with no reliable treatment for HIV infection, early diagnosis is a critical factor in managing AIDS patients, as it is a major cause for morbidity and mortality globally. Furthermore, the point-of-care technologies have enabled efficient monitoring of heart rate, inflammation threats, and heart failure that can potentially avert complications, reduce economic burden, and improve patient care across diverse medical and home care settings. According to the American Heart Association, cardiovascular diseases account for 17.3 million deaths per year globally and by 2030, around 23.3 million people are expected to die from CVD.

Increasing cancer and diabetes incidences is one of the major factors driving demand for point of care diagnostic tools and assays. Monitoring of glucose, hemoglobin, ketones, and other factors allows prevention and early detection of diabetes-related acute and chronic complications, and has a positive impact on the process of care and management of patients with diabetes. According to National Cancer Institute, in 2016, around 16.8 million new cases of cancer were diagnosed in the U.S., with around 595,690 deaths from the same disease. The number of people suffering from cancer is expected to rise to 19 million by 2024. According to the Global Diabetes Community, in 2017, around 422 million adults suffer from diabetes globally, where the number is expected to escalate to 642 million by 2040.

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Key Vendors:

Advanced Liquid Logic, Inc., Agilent Technologies, Axxicon Moulds Eindhoven B.V., Lifesensors, Inc., Abbott Laboratories, Siemens Healthineers, and LifeScan, Inc.

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Systemic Lupus Erythematosus Treatment Market Opportunity Analysis 2018-2026

Systemic Lupus Erythematosus (SLE) is chronic autoimmune disorder. It is characterized by excess production of the antibodies that attacks body’s own cells and vital organs. Various symptoms associated with the disease includes joint pain, swelling, rashes over face (butterfly rash) and other body area, severe fatigue, hair loss, anemia, and Raynaud’s phenomenon etc. SLE can also affect vital body organs such as heart, kidney, lungs, and behavioral changes. Exact causes of the disease is unknown, however, hereditary and environmental factors could be lead to SLE.

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There is no direct cure available for SLE, however, symptomatic treatment can be administered to lower or eliminate symptoms associated with disease. Major classes of drugs commonly used are antimalarial agents such as chlorquine and hydrochlorquine; topical steroid cream for rashes; NSAIDS for joint pain; and fever steroidal medication such as glucocorticoids through IV or oral route and immunosuppressive agents to lower immune response from the antibodies.

Rise in incidence of SLE is one of major factors driving growth of the systemic lupus erythematosus treatment market. According to study published in the Expert Review of Clinical Immunology in 2017, the global incidence rate varied from about 0.3–23.7 per 100,000 person and the prevalence rates varied in the range from 6.5 to 178.0 per 100,000 people. Key companies are entering into collaborations for research and development in systemic lupus erythematosus, which is expected to support growth of the market.

For instance, in 2015, a genomic mapping company, 23andMe, Inc. collaborated with Pfizer, Inc. to study and understand the genetics of lupus thereby, to develop treatment for it. In 2012, Alliance for Lupus Research and Pfizer’s Centers for Therapeutic Innovation collaborated to discover new therapies for patients living with systemic lupus erythematosus. Increasing approvals for products for the treatment of SLE is another factor expected to aid in growth of the market. For instance, GlaxoSmithKline, in July 2017, received U.S.FDA approval for the subcutaneous form of its biologic drug belimumab for treatment of systemic lupus erythematosus. Clinical guidelines to include biologics in the treatment of systemic lupus erythematosus would further aid in market growth.

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Key Vendors:

GlaxoSmithKline Plc (GSK), F. Hoffmann-La Roche Ltd, Anthera Pharmaceuticals Inc., Bristol-Myers Squibb, Eli Lilly, Pfizer Limited, Merck KGaA, Immupharma Plc, Sanofi, Lycera Corporation, Aurinia Pharmaceuticals Inc., Mylan N.V., and Sandoz International GmbH.

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Aspergillosis Treatment Market Opportunity Analysis, 2018-2026

Aspergillosis is a group of diseases that occur from aspergillus infection. Aspergillus is a fungus whose spores are present in the air, but does not normally cause illness. Individuals with damaged lungs, sensitive immune system, and allergies are more prone to Aspergillus induced infection. Common Aspergillus infections include invasive Aspergillosis, non-invasive Allergic Pulmonary Aspergillosis (ABPA), and Chronic Pulmonary and Aspergilloma (CPA). Invasive aspergillosis is uncommon and occurs primarily in immunocompromised people.

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Chronic pulmonary aspergillosis is rare pulmonary disease, which increases symptoms of respiratory disorders such as asthma. According to a study published by European Respiratory Society (ERS) publications, in 2015, CPA is estimated to affect nearly 240,000 people in Europe. The most common form of CPA is Chronic Cavitary Pulmonary Aspergillosis (CCPA), which if left untreated can develop chronic fibrosing pulmonary aspergillosis. According to a statistics published by Centers for Disease Control and prevention, (CDC) an estimated 10% of individuals with asthma or cystic fibrosis experience an allergic reaction to aspergillus. ABPA is estimated to affect 2-15% of patients with cystic fibrosis and around 2% of all asthma patients.

Increasing prevalence of Aspergillosis and favorable government regulations are the major factors driving growth of the Aspergillosis treatment market. According to a study published in Journal of Fungi 2016, CPA is estimated to affect nearly three million people globally making it major health problem resulting in mortality and morbidity. Aspergillosis infection can be treated with antifungal and corticosteroids drugs. Corticosteroid drugs are prescribed for allergic bronchopulmonary aspergillosis treatment.

These drugs reduce inflammation and lowers respiratory symptoms such as coughing and wheezing. Some of the most frequently used drugs are methylprednisolone, prednisolone and prednisone. The U.S. Food & Drug Administration (FDA) approved various drugs for Aspergillosis infection treatment. For instance, in 2015, the U.S. FDA approved Isavuconazonium (Astellas Pharma), a prodrug form of Isavuconazole. Antifungal drugs are majorly used to treat invasive pulmonary Aspergillosis. Voriconazole, an antifungal drug is widely used due to less side effects and more effectiveness in comparison to other drugs. Itraconazole or Amphotericin B also treat the infection effectively. Caspofungin is used to treat infection, resistant to the other antifungals. Furthermore, antifungal drugs are sometimes used in combination with corticosteroids for treating ABPA. Surgeries may be required in some cases where aspergillomas are present leading to serious problems such as excessive bleeding. Antifungal drugs are generally not effective against aspergillomas, therefore surgery such as embolization is recommended. An aspergilloma is a solid mass of Aspergillus hyphae, mucus, fibrin, and other cellular debris, formed inside a pre-existing area of pulmonary cavity or scar.

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Key Vendors:

Abbott laboratories, AstraZeneca plc, Eli Lilly and Company, GlaxoSmithKline, Johnson & Johnson Services, Inc., Mylan Pharmaceuticals, Inc., Novartis AG, Pfizer, Inc., and Takeda Pharmaceutical Company Ltd.

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Disposable Oxygen Masks Market - Opportunity Analysis, 2018 - 2026

Disposable oxygen masks offers a medium to transfer breathing oxygen gas from a storage tank to the lungs. They feature a soft, air-filled cuff to allow a close fit to the patient's face with an easy grip and a dome with thumb rest, supplied with hook ring. Cushion and mask dome are made up of PVC (Polyvinyl chloride).

Disposable oxygen mask are wore on the face to protect nose & mouth from harmful gases and viruses in the environment that tend to cause infection. In healthcare sector, researchers and physicians usually wear disposable oxygen masks for safety from airborne infections.

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Moreover, disposable face masks are also used by patients suffering from diseases such as chronic obstructive pulmonary disease (COPD), asthma, and others. On the basis of product, disposable oxygen mask are available in the market as pediatric disposable oxygen masks and adult disposable oxygen masks.

For instance, according to the World Health Organization Forum of International Respiratory Societies 2017 report, around 65 million people suffer from COPD (chronic obstructive pulmonary disease) and 3 million die each year from COPD, making it the third major cause of death around the globe.Same report also revealed that around 334 million people suffer from asthma, the most common chronic disease in children affecting 14% of the children, globally. Lung cancer was the cause of death of 1.6 million people each year and pneumonia affects millions of people, annually which is the leading cause of death among the children below 5 years.

Moreover, increasing urbanization and industrialization is leading to poor air quality, which is playing vital factor in rising respiratory diseases and. For instance, according to the World Health Organization 2018 report, 4.2 million deaths every year are caused due to exposure to outdoor air pollution. Also, outdoor air pollution in both rural areas and cities was estimated to cause 4.2 million premature deaths worldwide in 2016. Owing to these factors, physicians advise patients for oxygen therapy using oxygen masks, which is propelling the global disposable oxygen market growth. However, availability of alternative products in the market such as nasal cannula are expected to hinder growth of disposable oxygen masks market size.

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Key Vendors:

Medline Industries, Inc., HEYER Medical AG, Dynarex, Drive Medical, Ambu A/S, Besmed Health Business Corp, BLS Systems Limited, Flexicare Medical Limited, and VYAIRE MEDICAL INC.

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Procalcitonin Antibody Market - Opportunity Analysis, 2018 - 2026

Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, and belongs to calcitonin (CT) superfamily of peptides. Procalcitonin is a 116 amino acid peptide that has an estimated molecular weight of 14.5 kDa. It can be segregated into three parts, namely immature calcitonin, calcitonin carboxyl-terminus peptide-1, and amino terminus of the PCT region. Procalcitonin was first classified by Bernard Roos and Leonard J. Deftos in the early 1970s. Procalcitonin is produced by C cells of the thyroid and by endocrine cells of the lung. In human body, level of unprocessed procalcitonin rises extensively after shock, injury or bacterial infection, which increases the production of procalcitonin in the body.

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This might lead to organ dysfunction and call for immediate treatment of the patient. The level of procalcitonin in the body can be diagnosed with wet lab analysis using procalcitonin antibody. On the basis of antibody type, the procalcitonin antibody market is segmented into polyclonal procalcitonin antibody and monoclonal procalcitonin antibody. For instance, according to the World Health Organization (WHO) fact sheet of 2018, cancer was responsible for 8.8 million deaths in 2015 globally. Moreover, according to the World Health Organization report of 2017, around 1.0 million deaths occurred due to HIV related illnesses worldwide. Furthermore, WHO 2017, fact sheet revealed that 71 million people were having chronic hepatitis C infection. Approximately 399,000 people die each year from hepatitis C, mostly from cirrhosis and hepatocellular carcinoma.

These incidences have led to the adoption of new techniques and procedures by research institutes and hospitals for quick diagnosis of the diseases, so that it can be treated within the earliest time frame. Moreover, increasing funding for research and development by commercial market players and government agencies for the development of efficient, safer, and innovative products for the treatment of diseases such as cancer is fueling growth of the procalcitonin antibody market. For instance, in 2018, the U.S government approved US$ 3 billion funds for the National Institutes of Health research and development activities.

Asia Pacific is expected to exhibit significant growth in the procalcitonin antibody market, followed by Europe, owing to increasing healthcare researches and rising geriatric population vulnerable to sepsis disease. According to the Center for Strategic and International Studies, in 2015, 9.5% of the population in China was 65 years or older and as per the United Nations, it is projected to reach to 27.5% by 2050.

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Key Vendors:

bioMerieux, HyTest, Roche Diagnostics, Snibe, Thermo Fisher Scientific, Vazyme Biotech, Hotgen Biotech, Getein Biotech, and Hangzhou Realy Tech Co., Ltd.

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Antimicrobial Wound Dressing Market Size, Share, Outlook 2026

Skin and Soft Tissue Infections (SSTIs) are one of the reason for high rate of morbidity and mortality. Even, in the cases of successful surgeries, affected subcutaneous tissue, fascia, or muscle; remains a delay in the healing process and can lead to life-threatening conditions. This cases are propelling demand for more effective treatments to deal with such pathological situations. Recently, wound dressings loaded with antimicrobial agents has emerged as potential option to reduce wound bacterial colonization and infection to improve the healing process.

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Antimicrobial wound dressing contains drugs such as antimicrobial agents, biologics such as growth factors, or they are composed of materials derived from animal sources. These dressings prevent bacterial penetration into the wound and avoid growth of microorganisms. The commonly encountered antiseptic agents in the antimicrobial dressings are silver, iodine, chlorhexidine, Polyhexamethylbiguanide (PHMB), alginate, and hydrocolloids. Conventional wound dressings take longer time for wound healing as compared to advanced wound dressing products such as antimicrobial and anti-infective wound dressings, which are widely used in post-operation to prevent risk of any Hospital Acquired Infections (HAIs). Antimicrobial wound dressings are rapidly replacing conventional wound dressings due to their high functional efficiency and effectiveness.

Increasing incidence of burns, trauma wounds and injuries, and diabetic ulcers are expected to drive growth of the global antimicrobial wound dressings market over the forecast period. For instance, in January 2017, according to the World Health Organization (WHO) data published in African Journal of Emergency Medicines, burn cases accounted for around 18 million disability cases and more than 2,50,000 deaths annually, out of which over 90% deaths were reported in low- and middle-income economies. The U.S. fire department responded to around 1.3 million fire incidences in 2016, out of which 3,280 civilian deaths and 15,700 civilian injuries were reported by National Fire Protection Association (NFPA).

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Key Vendors:

Smith & Nephew plc. ConvaTec Group plc. Medtronic plc. (Covidien plc.), Acelity L.P. Inc. (Kinetic Concepts, Inc.), Coloplast A/S, Mölnlycke Health Care, B. Braun Melsungen AG, and Paul Hartmann AG.

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Peptide Cancer Vaccine Market Global Insights, 2018-2026

Peptide cancer vaccines aids to elicit and expand tumor-specific T-cells capable of controlling or eradicating tumor. This vaccine consists of one or more short or long amino acid sequences as tumor antigens, combined with vaccine adjuvant. In the recent past, results of clinical trials performed using peptide cancer vaccine had exhibited negative outcomes. So, researchers in the peptide vaccine have considered this as outdated therapy and declared it as no longer viable for cancer treatment. However, increasing progress in understanding critical role of immune adjuvants, modes of vaccine administration, and T cell dynamics has led to re-emergence of this approach for treating malignant disorders.

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North America market accounted for the largest share in the global peptide cancer vaccine market, followed by Europe market in 2016. 

Furthermore, advantages involved in the preparation and usage of peptide vaccine are easy to synthesize, cost-effective, easy to prepare, and its application in clinical practice, flexibility in changing antigen, and lower risk of antigen-induced anaphylaxis are expected to foster growth of the peptide cancer vaccine market in the near future. Therefore, owing to these advantages, manufacturers are focusing on research, to develop peptide cancer vaccines. For instance, in April 2018, Boston Biomedical, Inc. involved in next generation cancer therapeutics, initiated dosing of the first patient in each of two clinical studies to evaluate the results of its affectability by using DSP-7888, an investigational cancer peptide vaccine. 

According to a National Cancer Institute, 2016, in the U.S., it was estimated that 16.8 million new cases of cancer were diagnosed with an approximate 595,690 deaths from the disease. The number of people with cancer is expected to rise to 19 million by 2024. Furthermore, the World Health Organization (WHO) reported around 14 million cases of cancer and 8.2 million deaths caused by the disease in 2012. Among these, the common cases pertained to lung, colorectal, prostate, cervical, and breast cancer, which significantly has increased demand for peptide vaccines, in turn aiding in growth of the global peptide cancer vaccine market.

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Key Vendors:

 TapImmune, Merck, BrightPath Biotherapeutics, Sellas, BioLife Science, Boston Biomedical, VAXON Biotech, Lytix Biopharma, ISA Pharmaceuticals, Generex Biotechnology, OncoTherapy Science, Enzo Life Science, Antigen Express, Immatics Biotechnologies, Immatics, Immune Design, Immunomedics, Galena Biopharma, Generex Biotechnology Corporation, and Ultimovacs.

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Antisense Oligonucleotides Market Opportunity Analysis, 2018 – 2026

Antisense oligonucleotides are short, single stranded RNA or DNA molecules. Antisense oligonucleotides do not modulate the activity of already formed proteins, however they act before proteins are produced at the level of messenger RNA in the cell. Antisense oligonucleotides is used in treatment of oncology, Central nervous system therapeutics, inflammation therapeutics, diabetes, asthma, hair loss, etc. Antisense oligonucleotides is also used in genomics. Some examples of antisense nucleotides are fomivirsen to treat cytomegalovirus retinitis, mipomersen to treat high cholesterol, etc.

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One of the major factors driving growth of the global antisense oligonucleotides market is increasing number of launches pertaining to novel Antisense Oligonucleotides products by key players in the market. For instance, in 2015, Exiqon A/S acquired by Qiagen launched new LNA Antisense Oligonucleotide GapmeRs. LNA Antisense Oligonucleotide GapmeRs is used for inactivation of RNA in functional analysis. Antisense LNA is an alternative to existing siRNAs. LNA Antisense Oligonucleotide are designed using advanced bioinformatics algorithm, which is combined with LNA (locked nucleic acid).

Furthermore, mergers and acquisitions by key players, in order to enhance their product offerings is expected to be a major driver for global antisense oligonucleotides market growth. For instance, in February 2018, Takeda Pharmaceuticals Company Ltd.—a pharmaceutical company—merged with Wave Life Sciences Ltd., which is involved in nuclei acid therapeutics.

Takeda Pharmaceuticals has merged with Wave Life Sciences Ltd. to develop antisense oligonucleotides for central nervous system disorder, which includes Lou Gehrig’s disease, Frontotemporal dementia (FTD), Spinocerebellar ataxia type 3 (SCA3), and huntington’s disease. Lou Gehrig’s disease is also called as Amyotrophic lateral sclerosis (ALS). This acquisition will also help Takeda in gaining market share.

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Key Vendors:

Ionis Pharmaceuticals Inc., Sarepta Therapeutics Inc., Biogen Inc., Alnylam Pharmaceuticals Inc., Antisense Therapeutics Ltd., Isarna Therapeutics GmbH, Arrowhead Pharmaceuticals Inc., Atlantic pharmaceuticals Inc., Enzon Pharmaceuticals Inc., Bio-Path Holdings Inc., Glaxo smith Kline Plc., Gene Signal International SA., Geron Corporation, Gradlis Inc., ICO Therapeutics Inc., Aptose Biosciences Inc., Marina Biotech Inc., miRagen Therapeutics Inc., Synlogic Inc., OncoGenex Pharmaceuticals Inc., Pharmaxis Ltd., Rexahn Pharmaceuticals Inc., Regulus Therapeutics Inc., and Rxi Pharmaceuticals Inc.


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Helicobacter Pylori Diagnostics Market Global Forecast to 2026

Helicobacter is a spiral shaped gram-negative bacteria, causing chronic inflammation and infection in stomach and duodenum leading to ulceration. H. pylori is found in 50-80% of patients with gastric ulcers and in 90% of patients with duodenal ulcers. An estimated one in six individuals infected with H. pylori are expected to eventually develop peptic ulcer disease. Infected individuals experience long asymptomatic conditions with nearly 70% of individuals having minimal symptoms such as belching, bloating, nausea, vomiting, abdominal discomfort as occasional, whereas, major symptoms includes abdominal pain, peptic ulcer, bad breath etc.

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Helicobacter infection can be diagnosed by invasive that requires gastric mucosa samples, which are obtained through endoscopy and used for biopsy or non-invasive tests that requires blood or stool samples. Invasive tests include immunoassay, rapid urease test, and histology whereas non-invasive includes stool antigen assays serology tests and urea breath test.

Prevalence of helicobacter pylori is declining in developed countries, whereas its prevalence in emerging economies is increasing. For instance, according to the Faculty of Medicine of The Chinese University of Hong Kong (CUHK), 2017, around 4.4 billion people worldwide are infected with Helicobacter pylori (H. pylori). Furthermore, same source suggested that prevalence in Africa is up to 80%, which is the highest globally, while in Asia, over 50% of the population was infected with H. pylori. Moreover, according to the International Agency for Research on Cancer report 2014, in 2012, around 952,000 new gastric cancer cases occurred globally and around 734,000 gastric cancers were estimated to occur due to H. pylori infection. Such high prevalence of Helicobacter pylori in Africa and Asia is expected to fuel the regional helicobacter market growth.

The limitations associated with diagnostic tests are expected to be a major factor restraining growth of the Helicobacter pylori diagnostics market. For instance, serology-based assays have low sensitivity and specificity, as they are unable to differentiate between active infection and IgG antibodies present in case of post treatment.

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Key Vendors:

Thermo Fisher Scientific, Inc., Bio-Rad Laboratories Inc., Diasorin S.P.A., Quidel Corporation, F. Hoffmann-La Roche Ltd.(Ventana Medical Systems, Inc.), Meridian Bioscience, Inc., Exalenz Bioscience Ltd., Abbott Laboratories, Cardinal Health, Inc., and Halyard Health, Inc.

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Retroperitoneal Liposarcoma Treatment Market Share, Outlook 2026

Retroperitoneal liposarcoma (RLS) is a rare, biologically heterogeneous cancer, which occurs in retroperitoneum, lining of the abdominal space that covers the abdominal organs. Retroperitoneal liposarcoma grow continuously and may not get diagnosed until they are very large thus, its prognosis is poor compared to the other subtypes of retroperitoneal sarcomas. The reason for the development of these tumors are still unknown, however, genetic mutation is considered to be one of the factors leading to the generation of these tumors. Incidence of this disease is equal in men and women, with a slight predominance of men. This tumor has no characteristic symptoms and are usually diagnosed during the advanced stage.

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Furthermore, the effectiveness of radiotherapy or chemotherapy for the treatment of this tumor is not properly defined, as they are massive in size and might involve adjacent visceral organs and critical structures. However, affected population who received adjuvant chemotherapy showed survival benefits and improvement, as compared to patients who underwent surgery alone. In the case of surgeries, sometimes, preoperative radiation is given to shrink the tumor. This allows smaller doses of radiation to a smaller field and make the surgery technically more feasible.

The European Organisation for Research and Treatment of Cancer (EORTC) is currently conducting a randomized trial comparing 50.4 Gy (Gray-unit to measure radiation therapy) of pre-operative radiation therapy with short-course radiotherapy, followed by surgery to direct surgery alone. Thus, continuous researches that are being conducted for the development of treatment for this disease is expected to create lucrative opportunities in the retroperitoneal liposarcoma treatment market during the forecast period.

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Key Vendors:

Eli Lilly and Company, Baxter International, Bristol Laboratories Ltd., Pfizer Inc., Teva Pharmaceutical Industries Ltd., Mylan N.V., Actavis plc, Fresenius Kabi Ltd., Accord Healthcare Inc., Taro Pharmaceuticals Inc., Sandoz, Bedford Laboratories, and Zydus Cadila.

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Immunostimulatory Adjuvants Market - Opportunity Analysis 2018-2026

Adjuvant is an integral part of a vaccine that helps to develop strong immune response in the human body. Conventional vaccines are derived from toxin, inactivated whole organism, and live-attenuated, which are effective in stimulating antibody-based immunity. Adjuvants are used to enhance efficiency of vaccines as conventional vaccines are highly reactogenic in nature. Various molecules have been considered for use as an adjuvant, such as mineral salts, oil emulsions, microbial derivatives, particulate adjuvants, and plant derivatives.

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Based on the mechanism of action, the adjuvants are categorized into two types, which include particulate vaccine delivery systems that specifically target antigen to antigen presenting cells (APCs) and the immunostimulatory adjuvants that interacts with toll like receptors (TLRs) of the cell resulting in inflammatory response that amplify the innate immune response. Increasing government initiatives to prevent epidemic due to various chronic diseases and increasing national immunization programs around the globe to promote health awareness regarding vaccination among the population has boosted the growth of the immunostimulatory adjuvants market size.

The global immunostimulatory market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America immunostimulatory adjuvants market holds the dominant position in terms of revenue. Moreover, Presence of major market players in U.S. region and increasing federal support towards the growth of healthcare sector is propelling growth of the immunostimulatory adjuvant market.

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Key Vendors:

Bayer, Adjuvance Technologies, Vical, Allergy Therapeutics, BioCenturay, and Recenttec.

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HPV and Pap Testing Market Opportunity Analysis, 2018-2026

HPV stands for human papillomavirus, which constitutes a group of more than 150 related viruses. Every HPV virus has a number or a type. HPVs are attracted to only a specific cell type known as squamous epithelial cells and the viruses can live only in these cells. Some of the human papillomavirus can cause non-cancerous tumors while others can lead to cancer, which includes cancer of the cervix, vagina, vulva, anus, penis, and parts of mouth and throat that comprises mostly of the moist skin in the body. These types of HPVs are considered to be mucosal, as they invade in the living cells on mucosal surfaces.

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Diagnosis and treatment of the abnormal cells developing in the cervix help in the prevention of cervical cancer. The two most common tests employed to check the behavior of cervical cells are HPV and Pap tests. The Pap test is a simple smear test, which provides an effective screening measure to determine whether the cervical cells are normal or abnormal. HPV testing is performed to screen for human papillomavirus in the cervix that can lead to cervical cancer. A person observed with abnormal cells through Pap test is recommended to opt for HPV testing for further evaluation of cervical cancer. According to the National Cervical Cancer Coalition 2017, around 12,000 women are diagnosed with cervical cancer per year in the U.S. Moreover, the American Sexual Health Association (ASHA) suggests that cervical cancer is amongst one of the most preventable types of cancer. These cancers can be prevented through early detection and treatment of abnormal cell changes that occurs in the cervix prior to the development of cervical cancer cells.

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Moreover, technological advancements in improving the existing accuracy of HPV testing is also expected to drive growth of global HPV testing and Pap test market. For instance, in April 2014, Roche Molecular Systems received FDA approval for Cobas HPV test as a primary screening test that would facilitate mitigation of late-stage survival cancer. However, the inaccuracy of smear based Pap test leading to low reliability is expected to hamper growth of the global HPV and Pap testing market.

Key Vendors:
Qiagen N.V., Abbott Laboratories, Becton, Dickinson & Company, Hologic, Inc., Quest Diagnostics, Femasys, Inc., Roche Diagnostics, Arbor Vita Corporation, Onco Health Corporation, Seegene, Inc., and others. 

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Coherent Market Insights is a prominent market research and consulting firm offering action-ready syndicated research reports, custom market analysis, consulting services, and competitive analysis through various recommendations related to emerging market trends, technologies, and potential absolute dollar opportunity.

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Coherent Market Insights
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