Low Molecular Weight Heparins (LMWH) are a form of pharmacological anticoagulant intervention. Low molecular weight heparin is used for prophylaxis of deep vein thrombosis and pulmonary embolism, or thrombosis occurring in a broad spectrum of clinical indications, including general or orthopaedic surgery, neurosurgery, trauma, unstable angina, and myocardial infarction. LMWHs are derived from UFH by chemical or enzymatic depolymerisation to yield fragments that are around one third the size of heparin.
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However, it is associated with higher anticoagulant effect and provides higher bioavailability after subcutaneous administration, as compared to unfractionated heparin (UFH), for thromboembolic indications. Low molecular weight heparin is the most suitable anticoagulant in case of complicated pregnancy, as it eliminates risk of crossing the placental membrane. Low molecular weight heparin market growth attributed to advantages of low molecular weight heparin over unfractionated heparin. Unfractionated heparin or standard heparin varies in action from patient to patient. Thus, it can only be administered by hospitalized patients under monitoring, while low molecular weight heparin can be used subcutaneously once a day, without the need for monitoring.
Increasing inclination of research institutes towards developing novel alternatives for available LMWH treatments is expected to widen the range of therapies, while narrowing down its side effects. For example, American University of Beirut Medical Centre sponsored the study for a drug, bemiparin sodium (a form of LMWH), which is in phase 4 and is expected to be completed in mid-2018, to improve the pregnancy outcomes in patients with recurrent implantation failure undergoing IVF/ ICSI treatment.Additionally, companies are collaborating with hospitals to strengthen their product portfolio. For instance, Bayer in collaboration with Assistance Publique - Hopitaux de Paris is studying combination of rivaroxaban and low molecular weight heparin for neoplasm and venous thromboembolism, which is in phase 3. Both these pipeline drugs are expected to complete their final stages of study during the forecast period, which in turn is expected to enhance the low molecular weight heparin market.
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Sanofi, Amphastar Pharmaceutical Inc., Teva Pharmaceuticals Industries Inc., Pfizer, Inc., LEO Pharmaceutical Products, Celgene Corporation, Sandoz GmbH (a division of Novartis AG), and Changzhou Qianhong Bio-pharma co. Ltd.
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